According to usatoday.com, Jim Parsons, the actor who played Sheldon, was sick during the worst time. During the fourth season of the series, there's a very important scene between Sheldon and Amy, which was much less pleasant than it looked because Jim was sick with the flu at the time.
Actress Melissa Rauch portrayed Bernadette, who was a very feisty character on the show. But in real life, Melissa is more laid back, and she had to be pushed to be more assertive, according to usatoday.
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