Jo Understands Alex Completely
Jo Wilson truly understands Alex Karev. She knows where he comes from and why he is the way he is, loving him unconditionally despite his flaws. This deep understanding allows them to have a strong, resilient relationship, as Jo is always there for Alex, even during tough times.
Izzie's Disappearing Act
In contrast, Izzie Stevens left Alex heartbroken when she disappeared after being fired from the hospital. Despite Alex’s unwavering support during her illness, Izzie chose to leave him without explanation, showing a lack of commitment that hurt Alex deeply.
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