It started with an iconic on-screen friendship. Amy Farrah Fowler and Penny, two women who couldn’t have been more different, forming an unlikely bond that became one of the most beloved dynamics of The Big Bang Theory. But while their characters shared laughs, heartbreak, and moments of sisterhood on-screen, the real-life relationship between the actresses, Mayim Bialik and Kaley Cuoco, was not as harmonious.
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