Rachel DiPillo exited as a regular after three seasons, when Dr. Sarah Reese decided to abandon pathology and transferred to Baylor following a rough conflict with her mentor. She vanished from primetime for a while — but fans welcomed her back in a guest arc in Season 10.
Colin Donnell left after a dramatic storyline involving the death of his ex-girlfriend and his father — a decision driven by narrative closure rather than character death.
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