After more than two decades on the air, Grey’s Anatomy has built a reputation for doing one thing exceptionally well: breaking hearts. Plane crashes, shootings, sudden illnesses — longtime viewers have learned never to get too comfortable with their favorite characters.
Some deaths sparked outrage. Others left fans quietly sobbing on their couches. But not every loss hit the same behind the scenes.

Ask almost any fan which Grey’s Anatomy death hurt the most, and you’ll likely hear the same name: Derek Shepherd.
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