Acute inflammation is your immune system working correctly — it shows up after injury, fights infection, and resolves within days. Chronic inflammation is something entirely different: a persistent, low-level immune activation that never switches off, driven by diet, stress, poor sleep, and environmental exposures.
Sign #1: You're always tired, even when you've slept enough.
Inflammatory cytokines — specifically IL-6 and TNF-alpha — directly suppress mitochondrial energy production and cross the blood-brain barrier to produce fatigue and cognitive dulling.
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